4CI3
Structure of the DDB1-CRBN E3 ubiquitin ligase bound to Pomalidomide
Summary for 4CI3
Entry DOI | 10.2210/pdb4ci3/pdb |
Related | 2B5L 2B5M 3E0C 3EI1 3EI2 3EI3 3EI4 4A11 4CI1 4CI2 |
Descriptor | DNA DAMAGE-BINDING PROTEIN 1, PROTEIN CEREBLON, ZINC ION, ... (4 entities in total) |
Functional Keywords | dna binding protein, ddb1, crbn, cullin, e3 ligase, ubiquitin, thalidomide, contergan |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 2 |
Total formula weight | 183559.73 |
Authors | Fischer, E.S.,Boehm, K.,Thoma, N.H. (deposition date: 2013-12-05, release date: 2014-07-16, Last modification date: 2023-12-20) |
Primary citation | Fischer, E.S.,Bohm, K.,Lydeard, J.R.,Yang, H.,Stadler, M.B.,Cavadini, S.,Nagel, J.,Serluca, F.,Acker, V.,Lingaraju, G.M.,Tichkule, R.B.,Schebesta, M.,Forrester, W.C.,Schirle, M.,Hassiepen, U.,Ottl, J.,Hild, M.,Beckwith, R.E.J.,Harper, J.W.,Jenkins, J.L.,Thoma, N.H. Structure of the Ddb1-Crbn E3 Ubiquitin Ligase in Complex with Thalidomide. Nature, 512:49-, 2014 Cited by PubMed: 25043012DOI: 10.1038/NATURE13527 PDB entries with the same primary citation |
Experimental method |
Structure validation
Download full validation report